Book Name: Greenspan’s Basic and Clinical Endocrinology 10th Edition
Author: David Gardner, Dolores Shoback
Publisher: McGraw-Hill Education / Medical
File format: PDF
Greenspan’s Basic and Clinical Endocrinology 10th Edition Pdf Book Description:
Greenspan’s Basic & Clinical Endocrinology provides a succinct, leading-edge summary of the inherent molecular biology of the endocrine system and the most recent perspectives on the identification and treatment of particular ailments and ailments. Featuring an improved design that includes countless full-color illustrations and clinical photographs, Greenspan’s is an actual must-have through conventional or integrated classes in endocrinology, endocrinology spinning, or test prep in internal medicine and endocrinology and in regards for illness management. This represents the tenth edition of Greenspan’s Basic & Clinical Endocrinology a bittersweet milestone in that it also marks the recent passing of Dr. Francis Greenspan, the originator and namesake of this textbook. Frank’s involvement with this textbook will be sorely missed in the years to come. As with each of the previous editions, the individual chapters have been revised and updated to contain the most current information in the field. Our contributors continue to provide comprehensive content in a highly readable format.
Hormones are signaling molecules that traffic information from one point to another, typically through a soluble medium like the extracellular fluid or blood. Hormones fall into one of a number of different hormonal classes (eg, steroids, monoamines, peptides, proteins, and eicosanoids) and signal through a variety of general (eg, nuclear vs cell surface) and specific (eg, tyrosine kinase vs phosphoinositide turnover) mechanisms in target cells. Hormones produced in one tissue may promote activity in a target tissue at some distance from the point of secretion (endocrine effect). In this case the hormone travels through the bloodstream, often bound to a plasma protein, to access the target tissue. In addition, hormones may act locally following secretion; either on a neighboring cell (paracrine effect), on the secretory cell itself (autocrine effect), or without actually being released from the secretory cell (intracrine effect) (Figure 1–1). Identification of a tissue as a target for a particular hormone requires the presence of receptors for the hormone in cells of the target tissue. These receptors, in turn, are linked to effector mechanisms that lead to the physiological effects associated with the hormone. Greenspan’s provides clinically important protection of metabolic bone disease, pancreatic tissues and diabetes mellitus, hypoglycemia, obesity, geriatric endocrinology, and a number of different ailments and ailments. Supporting this crucial substance is a useful appendix of hormone benchmark ranges throughout the life span.
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