Book Name: Natural Killer Cell Protocols: Cellular and Molecular Methods Volume 121
Author: Marina Cella, Marco Colonna (auth.), Kerry S. Campbell, Marco Colonna
Publisher: Humana Press
File size: 2 MB
File format: PDF
Natural Killer Cell Protocols: Cellular and Molecular Methods Volume 121 Pdf Book Description:
Our comprehension of the phenotypical and functional heterogeneity of human all-natural killer (NK) cells has significantly improved over the previous couple of decades. This progress has been greatly aided by the growth of culture conditions such as clonal growth of NK cells. Analysis of individual NK cell clones has caused the original observation that distinct NK cell clones recognize different significant histocompatibility complex (MHC) class I specificities. In the mouse, the course I certain receptors identified thus far fit to the polymorphic Ly49 receptor family. Engagement of Ly49 receptors using their individual MHC ligands leads to negative regulation of NK cell effector functions, consistent with a crucial function of the receptors in”itself” recognition. The Ly49 receptors examined up to now are clonally distributed such that numerous different Ly49 receptors could be extracted by different NK cells. The finding that many NK cells which express the Ly49A receptor do this from one Ly49A allele (whereby expression may happen from the maternal or the paternal chromosome) may thus reflect a putative receptor supply process that limits the Amount of Ly49 receptors expressed in One NK cell
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